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Meds that Interfere with Skin Testing


Generic Name Brand Name Generic Name Brand Name Comments:
Newer Antihistamines (3-5 days) Hetero-cyclics (5-10 days)**
cesloratadine Clarinex amitriptyline Elavil
The medications in the right column are often used to treat depression, mood disorders, insomnia, nausea, muscle spasm, fibromyalgia and chronic pain. 
 
Unfortunately, they can interfere with skin testing.  However:  Do Not Stop These On Your Own.** We do not want to flare or make your other medical or psychiatric conditions worse!
If you are taking one of these, then before skin testing, you should ask your primary care doctor (or the doctor who prescribed it) if you can taper off these medications before skin testing -- stopping for the number of days before testing as annotated. 
 
If tapering off these agents is not possible, then we may have to evaluate by allergy RAST/ Immunocap "blood testing."  Allergy "blood testing" is more expensive but not affected by any of these medications.  
 
If you come for testing on one of these medications, sometimes, before ordering the more expensive blood testing, we may first check a "histamine control" prick test.  
 
If the histamine control is strongly reactive, (ie: despite having this antihistamine like medication in your system), then we may go ahead and do full skin testing.  A strong "histamine response" would lead us to believe that your skin can react to the allergens too, despite having this medicine in your system.
cetirizine Zyrtec clomipramine Anafranil
fexofenadine Allegra desipramine Norpramin
levoceterizine Xyzal doxepin Sinequan
loratadine Claritin, Alavert imipramine Tofranil
nortriptyline Pamelor
Older Antihistamines (2-3 days) protriptyline Vivactil
brompheniramine Dimetapp, Drixoral trazodone Desyrel
chlorpheniramine Actifed, Triaminic, CTM
clemastine Tavist Neuroleptics (5-10 days)**
cyproheptadine Periactin aripiprazole Abilify
dexchlorpheniramine Polaramine chlorpromazine Thorazine
diphenhydramine Benadryl, Sominex clozapine Clozaril
doxylamine Unisom, SleepAid, others fluphenazine Prolixin
hydroxyzine Atarax, Vistaril haloperidol Haldol
meclizine Antivert olanzapine Zyprexa
promethazine Phenergan paliperidone Invega
perphenazine Perphenazine
Eye Drops  (2-3 days) Perphenazine Trilafon
azelastine Optivar pimozide Orap
emedastine Emadine quitiapine Seroquel
epinastine Elestat risperidone Risperdal
ketotifen Zaditor thioridazine Mellaril
levocarbastine Livostin thiothixene Navane
olopatadine Pataday, Patanol trifluoperazine Stelazine
ziprasidone Geodon
Nasal Sprays (2-3 days)
azelastine Astelin Anti-Nausea Meds (5-10 days)
olopatadine Patanase dimenhydrinate Dramamine
droperidol Inapsine
H2 Antagonist - Stomach Acid Reducers (12-24 hrs) metoclopramide Reglan
cimetidine Tagamet prochlorperazine Compazine
famotidine Pepsid prometazine Phenergan
nizatidine Axid scopolamine Transderm-Scop Patch
ranitidine Zantac thiethylperazine Torecan
trimethobenzamide Tigan
Please Note:
1) Over the counter meds that say "PM," "Night-time Relief," "Allergy, Cold or Sinus" as part of the name probably have an antihistamine as one of the active agents so stop them for 1-2 days, just to be safe.  Muscle Relaxors (5-10 days)
chlorzoxazone Parafon Forte
cyclobenzaprine Flexeril
orphenadrine Norflex
2) Sudafed or pseudoephedrine is a decongestant (ie: not an antihistamine) so is fine to continue as long as it is not mixed with an antihistamine (ie: Claritin-D, etc).  
3) You can continue on your asthma meds - ie: singulair & sprays; nasal steroid sprays (ie: flonase, fluticasone, nasonex, rhinocort, nasacort, omnaris, flunisolide); ipratropium nasal spray; and other meds not on this list as they shouldn't interfere with skin testing.   If your not sure, ask your doctor, pharmacist, or call us.